AIMP1 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comAIMP1 Polyclonal Antibody for Human(Homo sapiens)

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AIMP1 (Gene name),

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Protein name ), AIMP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

AIMP1(EMAP2;SCYE1);

Protein name:

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;

Alternative:

Multisynthase complex auxiliary component p43;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts (via N-terminus) with RARS (via N-terminus). Interacts (via C-terminus) with SMURF2. Interacts (via N-terminus) with HSP90B1/gp96 (via C-terminus). Interacts with PSMA7.

Function:

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

Subcellular Location:

Nucleus Cytoplasm cytosol Cytoplasmic vesicle secretory vesicle Secreted Endoplasmic reticulum Golgi apparatus Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death.

Protein Attributes:

Sequence length:

312

Sequence:

50:

100:

150:

200:

250:

300:

312:

CRAQTMSNSG | IK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q12904

KEGG:

hsa:9255

Pfam:

PF01588

String:

Q12904

UniGene:

Hs.591680

MIM:

260600

STRING:

9606.ENSP00000378191

Uniprot:

Q12904

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ELISA Kit for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Cat.:

E2214h

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MSDS:

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Packing:

96T

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ELISA Kit for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Cat.:

E2214m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Cat.:

U2214m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Cat.:

U2214h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Cat.:

P2214Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Cat.:

P2214Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Protein for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II."
Kao J. , Houck K. , Fan Y. , Haehnel I. , Libutti S.K. , Kayton M.L. , Grikscheit T. , Chabot J. , Nowygrod R. , Greenberg S. , Kuang W.J. , Leung D.W. , Hayward J.R. , Kisiel W. , Heath M. , Brett J. , Stern D.M.
J. Biol. Chem.269:25106-25119(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-79
2.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Pancreas.
5.

"Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase."
Park S.G. , Jung K.H. , Lee J.S. , Jo Y.J. , Motegi H. , Kim S. , Shiba K.
J. Biol. Chem.274:16673-16676(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RARS
6.

"Prostate adenocarcinoma cells release the novel proinflammatory polypeptide EMAP-II in response to stress."
Barnett G. , Jakobsen A.-M. , Tas M. , Rice K. , Carmichael J. , Murray J.C.
Cancer Res.60:2850-2857(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;CLEAVAGE
7.

"The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component."
Shalak V. , Kaminska M. , Mitnacht-Kraus R. , Vandenabeele P. , Clauss M. , Mirande M.
J. Biol. Chem.276:23769-23776(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
8.

"Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis."
Park S.G. , Kang Y.-S. , Ahn Y.H. , Lee S.H. , Kim K.-R. , Kim K.-W. , Koh G.Y. , Ko Y.-G. , Kim S.
J. Biol. Chem.277:45243-45248(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Monocyte cell adhesion induced by a human aminoacyl-tRNA synthetase-associated factor, p43: identification of the related adhesion molecules and signal pathways."
Park H. , Park S.G. , Lee J.-W. , Kim T. , Kim G. , Ko Y.-G. , Kim S.
J. Leukoc. Biol.71:223-230(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII."
Wolfe C.L. , Warrington J.A. , Davis S. , Green S. , Norcum M.T.
Protein Sci.12:2282-2290(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
11.

"Structural separation of different extracellular activities in aminoacyl-tRNA synthetase-interacting multi-functional protein, p43/AIMP1."
Han J.M. , Park S.G. , Lee Y. , Kim S.
Biochem. Biophys. Res. Commun.342:113-118(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGIONS INVOLVED IN FIBROBLAST PROLIFERATION; ENDOTHELIAL CELL DEATH AND ENDOTHELIAL MIGRATION
12.

"Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines."
Bottoni A. , Vignali C. , Piccin D. , Tagliati F. , Luchin A. , Zatelli M.C. , Uberti E.C.
J. Cell. Physiol.212:293-297(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RARS
13.

"Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome."
Tandle A.T. , Calvani M. , Uranchimeg B. , Zahavi D. , Melillo G. , Libutti S.K.
Exp. Cell Res.315:1850-1859(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PSMA7
14.

"Pelizaeus-Merzbacher-like disease caused by AIMP1/p43 homozygous mutation."
Feinstein M. , Markus B. , Noyman I. , Shalev H. , Flusser H. , Shelef I. , Liani-Leibson K. , Shorer Z. , Cohen I. , Khateeb S. , Sivan S. , Birk O.S.
Am. J. Hum. Genet.87:820-828(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HLD3
15.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
18.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases."
Kim Y. , Shin J. , Li R. , Cheong C. , Kim K. , Kim S.
J. Biol. Chem.275:27062-27068(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 147-312
20.

"Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry."
Renault L. , Kerjan P. , Pasqualato S. , Menetrey J. , Robinson J.-C. , Kawaguchi S. , Vassylyev D.G. , Yokoyama S. , Mirande M. , Cherfils J.
EMBO J.20:570-578(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 148-312;FUNCTION

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